Inflammatory cytokines kinetics define the severity and phase of nephropathia epidemica.

Authors: Baigildina AA, Khaiboullina SF, Martynova EV, Anokhin VA, Lombardi VC, Rizvanov AA.
Link: http://www.ncbi.nlm.nih.gov/pubmed/25313675
Publication: Biomark Med. 2015;9(2):99-107. doi: 10.2217/bmm.14.88. Epub 2014 Oct 14.

AIMS: Nephropathia epidemica (NE) is a form of hemorrhagic fever with renal syndrome associated with the Puumala virus species of Hantavirus. The pathogenesis of NE is not well understood; therefore, investigating the inflammatory cytokine response to infection may provide useful knowledge in deciphering the pathophysiology of NE.
MATERIALS & METHODS: Using Luminex and ELISA, we analyzed the serum of 137 NE cases and 44 controls to investigate if serum cytokines associate with different clinical presentations.
RESULTS: Serum levels of TNF-α and IL-1β are associated with disease severity while upregulation of IL-6, CXCL10, CCL2 and CCL3 are associated with clinical presentation.
CONCLUSION: Inflammatory cytokine kinetics associate with the severity and phase of NE. Our data support a role for inflammatory cytokines in the pathophysiology of NE.